（2007年1月1日より12月末日まで）

地域保健医療研究部

  1. Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H. Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A 104: 2349-2354, 2007.
  2. Takizawa S, Takatsu K, Takaki S. Transient blocking of Lnk-mediated pathways as a potential approach to promote engrafting ability of hematopoietic progenitor cells.  Inflammation and Regeneration 27: 59-64, 2007.
  3. Yana I, Sagara H, Takaki S, Takatsu K, Nakamura K, Nakao K, Katsuki M, Taniguchi SI, Aoki T, Sato H, Weiss SJ, Seiki M. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. J Cell Sci 120: 1607-1614, 2007.
  4. Qin J, Konno H, Ohshima D, Yanai H, Motegi H, Shimo Y, Hirota F, Matsumoto M, Takaki S, Inoue J, Akiyama T. Developmental Stage-Dependent Collaboration between the TNF Receptor-Associated Factor 6 and Lymphotoxin Pathways for B Cell Follicle Organization in Secondary Lymphoid Organs. J Immunol 179: 6799-6807, 2007.
  5. Okawa-Takatsuji M, Nagatani K, Nakajima K, Itoh K, Kano T, Nagashio C, Takahashi Y, Aotsuka S, Mimori A. Recruitment of immature neutrophils in peripheral blood following leukocytapheresis therapy for rheumatoid arthritis. J Clin Apher 22: 323-329, 2007.
  6. Nakajima K, Itoh K, Nagatani K, Okawa-Takatsuji M, Fujii T, Kuroki H, Katsuragawa Y, Aotsuka S, Mimori A. Expression of BAFF and BAFF-R in the synovial tissue of patients with rheumatoid arthritis. Scand J Rheumatol 36: 365-372, 2007.

適正技術開発･移転研究部

  1. Naoshima-Ishibashi Y, Iwagami M, Kawazu S, Looareesuwan S, Kano S. Analyses of cytochrome b mutation in Plasmodium falciparum isolates in Thai-Myanmar border. Travel Med Infect Dis 5:132-4, 2007
  2. Mizuno Y, Kano S, Urashima M, Genka I, Kanagawa S, Kudo K. Simultaneous vaccination in Japanese travelers. Travel Med Infect Dis 5:85-9, 2007
  3. Krudsood S, Tangpukdee N, Muangnoicharoen S, Thanachartwet V, Luplertlop N, Srivilairit S, Wilairatana P,  Kano S, Ringwald P, Looareesuwan S. Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand. Korean J Parasitol 45:111-4, 2007
  4. Mi-Ichi F, Kano S, Mitamura T: Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum. Parasitology 134:1671-7, 2007
  5. Kobayashi T, Sato S, Takamiya S, Komaki-Yasuda K, Yano K, Hirata A, Onitsuka I, Hata M, Mi-ichi F, Tanaka T, Hase T, Miyajima A, Kawazu S, Watanabe Y, Kita K.Mitochondria and apicoplast of Plasmodium falciparum: behaviour on subcellular fractionation and the implication. Mitochondrion 7:125-3, 2207
  6. Iwagami M, Higo H, Miura S, Yanagi T, Tada I, Kano S, Agatsuma T. Molecular phylogeny of Trypanosoma cruzi from Central America (Guatemala) and a comparison with South American strain. Parasitol Res 102, 129-134, 2007
  7. Iwagami M, Taguchi N, Angluben RU, Escueta AS, Villacorte EA, Rivera PT, Kano S, Kawazu S. Evaluation of blood preservation methods in the performance of the WHO in vitro micro-test for Plasmodium falciparum in the field. Trop Med Health 35:337-341, 2007
  8. Shimada M, Kato-Hayashi N, Chigusa Y, Nakamura S, Ohmae H, Shinuon M, Socheat D, Kitikoon V, Matsuda H. High susceptibility of Neotricula aperta gamma-strain from Krakor and Sdau in Cambodia to Schistosoma mekongi from Khong Island in Laos. Parasitol Int 56:157-60, 2007.
  9. Hirose Y, Matsumoto J, Kirinoki M, Shimada M, Chigusa Y, Nakamura S, Sinuon M, Socheat D, Kitikoon V, Matsuda H. Schistosoma mekongi and Schistosoma japonicum: Differences in the distribution of eggs in the viscera of mice. Parasitol Int 56:239-41, 2007.
  10. Odermatt P, Habe S, Manichanh S, Tran D. S, Duong V, Zhang W, Phommathet K, Nakamura S, Barennes H, Strobel M, Dreyfuss G. Paragonimiasis and its intermediate hosts in a transmission focus in Lao People’s Democratic Republic. Acta Tropica 103:108-15, 2007
  11. 水野泰孝、工藤宏一郎、狩野繁之. 確定診断が困難であったアフリカからの三日熱マラリア輸入例　 感染症学雑誌 81:597-9, 2007
  12. 狩野繁之. 海外旅行者感染症 新感染症学（上）、日本臨牀65（増刊号2）:21-26，2007
  13. 石上盛敏、狩野繁之. 原虫（マラリア）の耐性化機序 新感染症学（上）、日本臨牀65（増刊号2）:497-501，2007
  14. 水野泰孝、狩野繁之. 海外渡航時に接種すべきワクチン 新感染症学（上）、日本臨牀65（増刊号2）:639-643，2007
  15. Rivera PT, Crisostomo BA, Villacorte EA, Escueta AD, Maekawa Y, Takagi M, Samaniego J, Ebol A, Kano S. GIS and Malaria Surveillance, A study in disaster-prone malarious provinces in the Philippines. Rivera PT and Kano S eds., Free Press Co, Tokyo, 2007.

消化器疾患研究部

  1. Mizutani, N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, and Dohi T, Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. J Immunol 79:7478-7487, 2007
  2. Hoshino, A, Kawamura YI, Yasuhara M, Toyama-Sorimachi N, Yamamoto K, Matsukawa A, Lira SA, and Dohi T, Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions. J Immunol 178:5296-5304, 2007
  3. Kawashima R, Kojima H, Nakamura K, Arahata A, Fujita Y, Tokuyama Y, Saito T, Furudate S, Kurihara T, Yagishita S, Kitamura K, Tamai Y.  Alterations in mRNA expression of myelin proteins in the sciatic nerves and brains of streptozotocin-induced diabetic rats.  Neurochemical Research 32(6):1002-10, 2007
  4. Tai LH, Goulet ML, Belanger S, Troke AD, St-Laurent AG, Mesci A, Toyama-Sorimachi N, Carlyle JR, Makrigiannis AP. Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.  Mol Immunol 10:2638-2646, 2007

呼吸器疾患研究部

  1. Mai HN, Hijikata M, Inoue Y, Suzuki K, Sakatani M, Okada M, Kimura K, Kobayashi N, Toyota E, Kudo K, Nagai H, Kurashima A, Kajiki A, Oketani N, Hayakawa H, Tanaka G, Shojima J, Matsushita I, Sakurada S, Tokunaga K, Keicho N. Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene. Int J Tuberc Lung Dis 11(7):808-13, 2007
  2. Hoshi S, Hijikata M, Togashi Y, Aoyagi T, Kono C, Yamada Y, Amano H, Keicho N, Yamaguchi T. Protein C deficiency in a family with thromboembolism and identified gene mutations. Intern Med 46(13):997-1003,2007
  3. Watanabe M, Uchida K, Nakagaki K, Kanazawa H, Trapnell BC, Hoshino Y, Kagamu H, Yoshizawa H, Keicho N, Goto H, Nakata K. Anti-cytokine autoantibodies are ubiquitous in healthy individuals. FEBS Lett 581(10):2017-21,2007
  4. Tanaka G, Shojima J, Matsushita I, Nagai H, Kurashima A, Nakata K, Toyota E, Kobayashi N, Kudo K, Keicho N. Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms. Eur Respir J 30(1):90-6,2007
  5. Horie T, Lien LT, Tuan LA, Tuan PL, Sakurada S, Yanai H, Keicho N, Nakata K. A survey of tuberculosis prevalence in Hanoi, Vietnam. Int J Tuberc Lung Dis 11(5):562-6,2007
  6. Keicho N, Matsushita I.  [Progress in the genetics of chronic obstructive pulmonary disease] Nippon Rinsho 65(4):611-4, 2007

代謝疾患研究部

  1. Osame K, Takasawa H, Watanabe S, Kishimoto M, Yasuda K, Kaburagi Y, Nakanishi K, Kajio H, Noda M, Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet auto antibody synthesis. Intern Med 46(12):873-7, 2007.
  2. Takasawa H, Takahashi Y, Abe M, Osame K, Watanabe S, Hisatake T, Yasuda K, Kaburagi Y, Kajio H, Noda M. An eldery case of type 2 diabetes which developed in association with oral and esophageal candidiasis. Intern Med 46(7):387-390, 2007.
  3. Nakahara M, Saeki K, Yogiashi Y, Kimura A, Horiuchi A, Nakamura N, Yoneda A, Saeki K, Matsuyama S, Nakamura M, Toda T, Kondo Y, Kaburagi Y, Yuo A. The protein expression profile of cynomolgus monkey embryonic stem cells in two-dimensional gel electrophoresis: a successful identification of multiple proteins using human databases. J Electrophoresis 51:1-8, 2007
  4. Kaburagi Y, Okochi H, Satoh S, Yamashita R, Hamada K, Ikari K, Yamamoto-Honda R, Terauchi Y, Yasuda K, Noda M. Role of IRS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins. Cell Struct Funct 32(1):69-78, 2007.
  5. Fukushima-Uesaka H, Saito Y, Maekawa K, Kamatani N, Kajio H, Kuzuya N, Noda M, Yasuda K, Sawada J-I. Genetic variations and haplotype structures of transcription factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese. Drug Metab Pharmacokinet 22(3):212-9, 2007.
  6. Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N. Search of type 2 diabetes susceptibility gene on chromosome 20q. Biochem Biophys Res Commun 357(4):1100-1106, 2007.
  7. Tsuchiya M, Yoshida T, Taniguchi S, Yasuda K, Maeda A, Hayashi A, Tanaka J, Shigemoto M, Nitta K, Tsuchiya K. In vivo suppression of mafA mRNA with siRNA and analysis of the resulting alteration of the gene expression profile in mouse pancreas by the microarray method. Biochem Biophys Res Commun 356(1):129-135, 2007.
  8. Fukushima-Uesaka H, Saito Y, Maekawa K, Hasegawa R, Suzuki K, Yanagawa T, Kajio H, Kuzuya N, Noda M, Yasuda K, Tohkin M, Sawada J-I. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. Drug Metab Pharmacokinet 22 (2) 129-135, 2007.
  9. Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y. Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett 581(1):91-6, 2007.
  10. Yamashita R, Fujiwara Y, Ikari K, Hamada K, Otomo A, Yasuda K, Noda M, Kaburagi Y. Extracellular proteome of human hepatoma cell line, Hep G2 analyzed using two-dimensional liquid chromatography coupled with tandem mass spectrometry. Mol Cell Biochem 298(1-2):83-92, 2007.
  11. Fukushima-Uesaka H, Saito Y, Tohkin M, Maekawa K, Hasegawa R, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Kajio H, Kuzuya N, Yasuda K, Sawada J. Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Drug Metab Pharmacokinet 22(1):48-60, 2007.

[Dr Nishida's group]

  1. MIYASKA.,T, ASAKURA.,T, NISHIDA., M et al. Meetings and of Articles and Reports Publish in the Journals-(Part1), Japanese Journal of Health Education and Promotion 15(1):33-66, 2007.
  2. MIYASKA.,T, ASAKURA.,T, NISHIDA., M et al. Meetings and of Articles and Reports Publish in the Journals-(Part2), Japanese Journal of Health Education and Promotion 15(2):110-131, 2007.

感染症制御研究部

  1. Sekiguchi J, Asagi T, Miyoshi-Akiyama T, Kasai A, Mizuguchi Y, Araake M, Fujino T, Kikuchi H, Sasaki S, Watarai H, Kojima T, Miki H, Kanemitsu K, Kunishima H, Kikuchi Y, Kaku M, Yoshikura H, Kuratsuji T, Kirikae T. Outbreaks of multi-drug resistant Pseudomonas aeruginosa in community hospitals in Japan. J Clin Microbiol 45: 979-989, 2007.
  2. Sekiguchi J, Miyoshi-Akiyama T, Augustynowicz-Kope? E, Zwolska Z, Kirikae F, Toyota E, Kobayashi I, Morita K, Kudo K, Kato S, Kuratsuji T, Mori T, Kirikae T. Detection of multi-drug resistance in Mycobacterium tuberculosis. J Clin Microbiol 45: 179-192, 2007.
  3. Hashimoto M, Furuyashiki M, Kaseya R, Fukada Y, Akimaru M, Aoyama K, Okuno T, Tamura T, Kirikae T, Kirikae F, Eiraku N, Morioka H, Fujimoto Y, Fukase K, Takashige K, Moriya Y, Kusumoto S, Suda Y. Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction. Infect Immun 75: 1926-1932, 2007.
  4. Zhao J, Hayashi T, Saarinen S, Papageorgiou AC, Kato H, Imanishi K, Kirikae T, Abe R, Uchiyama T, Miyoshi-Akiyama T. Cloning, expression and characterization of the superantigen streptococcal pyrogenic exotoxin-G from Streptococcus dysgalactiae. Infect Immun 75: 1721-1729, 2007.
  5. Huang Q, Tonge PJ, Slayden RA, Kirikae T, Ojima I. FtsZ: a novel target for tuberculosis drug discovery. Curr Top Med Chem 7: 527-543, 2007.
  6. Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell 130: 611-623, 2007.
  7. Sekiguchi J, Nakamura T, Miyoshi-Akiyama T, Kirikae F, Kobayashi I, Augustynowicz- Kope? E, Zwolska Z, Morita K, Suetake T, Yoshida H, Kato S, Mori T, Kirikae T. Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis strains. J Clin Microbiol 45: 2802-2807, 2007.
  8. Sekiguchi J, Teruya K, Horii K, Kuroda E, Konosaki H, Mizuguchi Y, Araake M, Kawana A, Yoshikura H, Kuratsuji T, Miyazaki H, Kirikae T. Molecular epidemiology of outbreaks and containment of drug-resistant Pseudomonas aeruginosa in a Tokyo hospital. J Infect Chemother 13: 418-422, 2007.
  9. Takahara M, Kirikae T. Mental hospital outbreak of Mycobacterium tuberculosis with few copies of IS6110 DNA fingerprinting. Kansenshogaku Zasshi 81: 741-744, 2007.
  10. Shimizu T, Kawakami S, Sato T, Sasaki T, Higashide M, Hamabata T, Ohta T, Noda M. The serine 31 residue of the B subunit of Shiga toxin 2 is essential for secretion in enterohemorrhagic Escherichia coli. Infect Immun 75: 2189-2200, 2007.
  11. Shimizu T, Sato T, Kawakami S, Ohta T, Noda M, Hamabata T. Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity. Microb Pathog 43: 88-95, 2007.
  12. Saarinen S, Kato H, Uchiyama T, Miyoshi-Akiyama T, Papageorgiou AC. Crystal structure of Streptococcus dysgalactiae-derived mitogen reveals a zinc-binding site and alterations in TcR binding. J Mol Biol 373:1089-1097, 2007.
  13. Ohara-Imaizumi M, Fujiwara T, Nakamichi Y, Okamura T, Akimoto Y, Kawai J, Matsushima S, Kawakami H, Watanabe T, Akagawa K, Nagamatsu S. Imaging analysis reveals mechanistic differences between first and second phase insulin exocytosis. J Cell Biol 177: 695-705, 2007.

血液疾患研究部

  1. Nakai-Murakami C, Shimura M, Kinomoto M, Takizawa Y, Tokunaga K, Taguchi T, Hoshino S, Miyagawa K, Sata T, Kurumizaka H, Yuo A, Ishizaka Y: HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene 26:477-486, 2007.
  2. Nakahara M, Saeki K, Yogiashi Y, Kimura A, Horiuchi A, Nakamura N, Yoneda A, Saeki K, Matsuyama S, Nakamura M, Toda T, Kondo Y, Kaburagi Y, Yuo A: The protein expression profile of cynomolgus monkey embryonic stem cells in two-dimensional gel electrophoresis: a successful identification of multiple proteins using human databases. J Electrophoresis 51:1-8, 2007.

難治性疾患研究部

  1. Kinomoto M, Kanno T, Shimura M, Ishizaka Y, Kojima A, Kurata T, Sata T, Tokunaga K. All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res 35,2955-64. 2007.
  2. Hoshino S, Sun B, Konishi M, Shimura M, Segawa T, Hagiwara Y, Koyanagi Y, Iwamoto A, Mimaya J, Terunuma H, Kano S, Ishizaka Y . Vpr in plasma of HIV type 1-positive patients is correlated with the HIV type 1 RNA titers. AIDS Res Hum Retroviruses 23,391-397, 2007
  3. Nakai-Murakami C., Shimura M, Takizawa Y, Tokunaga K, Taguchi T, Hoshino S, Miyagawa K, Sata T, Kurumizaka H, You A and Ishizaka Y. HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene 26, 477-86, 2007.
  4. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. (2007). Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.  Proc Natl Acad Sci U S A 104(46):18187-92, 2007

臨床薬理研究部（2006年）

  1. Nishikawa K, Kita E, Omata K, Igai K, Watanabe M, Yaffe MB, Natori Y: A multivalent peptide-library approach identifies a specific inhibitor for a carbohydrate-recognizing molecule. ASEB J 20:2597-2599, 2006
  2. Watanabe M, Igai K, Matsuoka K, Miyagawa A, Watanabe T, Yanoshita R, Samejima Y, Terunuma D, Natori Y, Nishikawa K: Structural Analysis of the Interaction between Shiga Toxin B Subunits and Linear Polymers Bearing Clustered Globotriose Residues. Infect Immun 74: 1984-1988, 2006
  3. Shibata N, Jishage K, Arita M, Watanabe M, Kawase Y, Nishikawa K, Natori Y, Inoue H, Shimano H, Yamada N, Tsujimoto M, Arai H: Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. FASEB J 20:2642-2644, 2006
  4. Yamada A, Hatano K, Matsuoka K, Koyama T, Esumi Y, Koshino H, Hino K, Nishikawa K, Natori Y, Terunuma D: Syntheses and Vero Toxin-Binding Activities of Carbosilane Dendrimers Periphery-functionalized with Galabiose. Tetrahedron 62:5074-5083, 2006
  5. Miyagawa A, Watanabe M, Igai K, Kasuya MCZ, Natori Y, Nishikawa K, Hatanaka K: Development of dialyzer with immobilized glycoconjugate polymers for removal of Shiga-toxin. Biomaterials 27:3304-3311, 2006
  6. Shin I, Nishikawa K, Maruya H, Ishii S: Histidine-tagged Shiga toxin B subunit binding assay: Simple and specific determination of Gb3 content in mammalian cells. Chem Pharm Bull 54:522-527, 2006
  7. 西川喜代孝：腸管出血性大腸菌感染症．Pharma Medica（メディカルレビュー社）、24:33-37, 2006
  8. 西川喜代孝：ベロ毒素を標的としたO157感染症治療薬．ファルマシア, 42:319-323, 2006

臨床病理研究部

  1. Shiroki F, Matsuda S, Doi T, Fujiwara M, Mochizuki Y, Kadowaki T, Suzuki H and Shigeo Koyasu S. The p85a regulatory subunit of classIA phosphoinositide 3-kinase regulates b-selection in thymocyte development.  J Immunol 178: 1349-1356, 2007
  2. Oda H, Suzuki H, Sakai K, Kitahara S, Patrick MS, Azuma Y, Sugi K, Kitamura T, Kaye J and Shirai M. Rac1 mediated Bcl-2 induction is critical in antigen-induced CD4 single positive differentiation of a CD4+CD8+ immature thymocyte line.   J Leuko Biol  81: 500-508, 2007  
  3. Murata M, Azuma A, Miura K, Mohd. Rahman MA, Matsutani M, Aoyama M, Suzuki H, Sugi K and Shirai M. Chlamydial SET domain protein functions as a histone methyltransferase  Microbiology 153: 585-592, 2007
  4. Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y. Melanocortin receptor 2 is required for adrenal gland development, steroidogenesis and neonatal gluconeogenesis. Proc Natl Acad Sci USA 104 :18205-18210, 2007
  5. Chida D, Iwakura Y. Peripheral TNFa, but not peripheral IL-1, requires endogenous IL-1 or TNFa induction in the brain for the febrile response. Biochemical and Biophysical Research Communications 364:765-770, 2007
  6. Sato Y, Kaneko K, Inoue M.  Macrolide antibiotics promote the LPS-induced upregulation of prostaglandin E receptor EP2 and thus attenuate macrolide suppression of IL-6 production.
    Prostaglandins Leukot Essent Fatty Acids 76 :181-118, 2007
  7. Hashimoto A, Hayashi I, Murakami Y, Sato Y, Kitasato H, Matsushita R, Iizuka N, Urabe K, Itoman M, Hirohata S, Endo H. Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. J Rheumatol 34: 2144-53, 2007
  8. Mizobe T, Tsukada J, Higashi T, Mouri F, Matsuura A, Tanikawa R, Minami Y, Yoshida Y, Tanaka Y. Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells.Exp Hematol  35: 1812-22, 2007
  9. Nakano K, Okada Y, Saito K, Tanikawa R, Sawamukai N, Sasaguri Y, Kohro T, Wada Y, Kodama T, Tanaka Y.  Rheumatoid synovial endothelial cells produce macrophage colony-stimulating factor leading to osteoclastogenesis in rheumatoid arthritis. Rheumatology 46: 597-603, 2007
  10. Furukawa Y, Vu HA, Akutsu M, Izumi T, Tsunoda S, Matsuo Y, Sato Y, Mano H, Kano Y Divergent cytotoxic effects of a tyrosine kinase inhibitor PKC412 in combination with antileukemic agents between FLT3 mutation-positive and negative leukemia cell lines.
    Leukmia 21: 1005-14, 2007

遺伝子診断治療開発研究部

  1. Wakahara S, Konoshita T, Mizuno S, Motomura M, Aoyama C, Makino Y, Kato N, Koni I, Miyamori I. Synergistic expression of ACE and ACE2 in human renal tissue and confounding effects of hypertension on the ACE/ACE2 ratio. Endoclinology 148:2453-7, 2007.
  2. Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N. Search of type 2 diabetes susceptibility gene on chromosome 20q. Biochem Biophys Res Commun 357:1100-6,2007.
  3. Jesmin S, Maeda S, Mowa CN, Zaedi S, Togashi H, Prodhan SH, Yamaguchi T, Yoshioka M, Sakuma I, Miyauchi T, Kato N. Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat. Eur J Pharmacol 574:158-71,2007.
  4. Fujimoto T, Koyanagi M, Baba I, Nakabayashi K, Kato N, Sasazuki T, Shirasawa S. Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line. J Hum Genet 52:978-84,2007.
  5. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-Density Association Study and Nomination of Susceptibility Genes for Hypertension in the Japanese National Project. Hum Mol Genet Epub 2007 Nov 14;
  6. Takeuchi F, Serizawa M, Kato N. HapMap coverage for SNPs in the Japanese population. J Hum Genet Epub 2007 Nov 28;
  7. Serizawa M, Nabika T, Ochiai Y, Takahashi K, Yamaguchi S, Makaya M, Kobayashi S, Kato N. Association between PRKCH Gene Polymorphisms and Subcortical Silent Brain Infarction. Atherosclerosis 2007 Dec 28;


国際臨床研究センター山本センター長

  1. Hoshino A, Nagao T, Nakasuga A, Ishida-Okawara A,Suzuki K, Yasuhara M, Yamamoto K, Nanocrystal Quantum Dot-Conjugated Anti-Myeloperoxidase Antibody as the Detector of Activated Neutrophils. IEEE Transactions on NanoBioscience 6(4):341-345, 2007
  2. Hoshino A, Ohnishi N, Yasuhara M, Yamamoto K, Kondo A. Separation of Murine Neutrophils and Macrophages by Thermoresponsive Magnetic Nanoparticles. Biotechnology Progress 23(6):1513-1516 ,2007
  3. Hoshino A, Omata K, Takami S, Adschiri T, Terada N, Funatsu T, Yasuhara M, Yamamoto K. Fluorescence Millisecond. Oscillation in Polar Solvents regulates Fluorescence Intensity of Colloidal Quantum Dots' solution. Journal of Nanophotonics 2007; (1) 013516(pp1-9), doi:10.1117/1.2767608 (E-pub only journal). PDF<http://www.geocities.jp/backenlab/data/ J.Artif.Organs._2007_Review.pdf>
  4. Hoshino A, Manabe N, Fujioka K, Suzuki K, Yasuhara M, Yamamoto K. Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine; surface modifi cation regulates biological function, including cytotoxicity. The Journal of Artificial Organs 10 (3) :149-157,2007
  5. Krevchik VD, Novikov TV, Dahnovsky YI, Semenov MB, Shcherbakova EV, Yamamoto K. Nonlinear Dynamics of Infectious Diseases Transfer with Possible Applications for Tubercular Infection. Arxiv Medical Physics 2007; 6 :1434. 11Jun 2007 arXiv:0706.1434v1 (E-pub only journal).
  6. Hoshino A, Nagao T, Ito-Ihara T, Ishida-Okawara A, Uno K, Muso E, Nagi-Miura N, Ohno N, Tokunaka K, Naoe S, Hashimoto H, Yasuhara M, Yamamoto K, Suzuki K. Trafficking of QD-conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis model mice. Microbiology and Immunology 51 (5) :551-566,2007
  7. Futamura Y, Yahara K, Yamamoto K. Evidence for the production of fluorescent pyradine delivertives using supercritical water. The Journal of Supercritical Fluids 2007;41(2)279-284 doi:10.1016/j.supflu.2006.10.008
  8. Hoshino A, Kawamura YI, Yasuhara M, Toyama-Sorimachi N, Yamamoto K, Matsukawa A, Lira SA, Dohi T. Inhibition of CCL1-CCR8 Interaction Prevents Aggregation of Macrophages and Development of Peritoneal Adhesions. The Journal of Immunology 178(8):5296-5304,2007
  9. Yamamoto S, Manabe N, Fujioka K, Hoshino A, Yamamoto K. Visualizing Vitreous using Quantum Dots as Imaging Agents. IEEE Transactions on NanoBioscience 6(1)94-98,2007

国際保健医療研究部

  1. Ohta M, Mizoue T, Mishima N, Ikeda M: Effect of the physical activities in leisure time and commuting to work on mental health. J Occup Health 49:46-52, 2007.
  2. Niijima K, Enta K, Hori H, Sashihara S, Mizoue T, Morimoto Y: The usefulness of sleep apnea syndrome screening using a portable pulse oximeter in the workplace. J Occup Health 49:1-8, 2007
  3. Wakai K, Nagata C, Mizoue T, Tanaka K, Nishino Y, Tsuji I, Inoue M, Tsugane S: Alcohol Drinking and Lung Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence among the Japanese Population. Jpn J Clin Oncol 37:168-174, 2007
  4. Kimura Y, Kono S, Toyomura K, Nagano J, Mizoue T, Moore MA, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N: Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Sci 98:590-597, 2007
  5. Ikeda A, Iso H, Toyoshima H, Fujino Y, Mizoue T, Yoshimura T, Inaba Y, Tamakoshi A; JACC Study Group: Marital status and mortality among Japanese men and women: the Japan Collaborative Cohort Study. BMC Public Health 7:73, 2007
  6. Pham TM, Fujino Y, Tokui N, Ide R, Kubo T, Shirane K, Mizoue T, Ogimoto I, Yoshimura T: Mortality and risk factors for stroke and its subtypes in a cohort study in Japan. Prev Med 44:526-530, 2007.
  7. Mizoue T, Tokunaga S, Kasai H, Kawai K, Sato M, Kubo T: Body mass index and oxidative DNA damage: A longitudinal study. Cancer Sci 98:1254-1258, 2007
  8. Yin G, Kono S, Toyomura K, Moore MA, Nagano J, Mizoue T, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N: Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Sci 98:1248-1253, 2007
  9. Ide R, Fujino Y, Hoshiyama Y, Mizoue T, Kubo T, Pham TM, Shirane K, Tokui N, Sakata K, Tamakoshi A, Yoshimura T; for the JACC Study Group: A Prospective study of green tea consumption and oral cancer incidence in Japan. Ann Epidemiol 17:821-826, 2007
  10. Pham TM, Fujino Y, Ide R, Shirane K, Tokui N, Kubo T, Mizoue T, Ogimoto I, Yoshimura T: Mortality attributable to cigarette smoking in a cohort study in Japan. Eur J Epidemiol 22:599-605, 2007
  11. Nagata C, Mizoue T, Tanaka K, Tsuji I, Wakai K, Inoue M, Tsugane S; for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol drinking and breast cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol 37:568-574, 2007
  12. Yoshida D, Kono S, Moore MA, Toyomura K, Nagano J, Mizoue T, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N: Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka Colorectal Cancer Study. Jpn J Clin Oncol 37:597-602, 2007
  13. Inoue M, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsuji I, Tsugane S; for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol drinking and total cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol 37:692-700, 2007
  14. Niijima K, Mizoue T, Kawashima M, Enta K, Sashihara S, Morimoto Y: Predisposing factors of sleep-disordered breathing in Japanese male workers. J Occup Health 49:461-466, 2007
  15. 松下由実: 栄養教育・栄養指導論<３訂>. 第11章　栄養教育の国際的動向151-159, 2007.
  16. 松下由実，野田光彦: 科学は動いている もっと知りたい！食事と疾患の関係 糖尿病の食事. 食生活 101:54-58, 2007.
  17. 松下由実，戸邉一之，原一雄，門脇孝: メタボリックシンドロームとインスリン抵抗性・糖代謝異常. 日本医師会雑誌 136(特別号(1)):S114-S119, 2007.
  18. 松下由実，戸邉一之，原一雄，門脇孝:メタボリックシンドロームは予防医学のなかで、どのように位置づけられますか？ 日本医師会雑誌 136(特別号(1)):S259-S260, 2007.

医療情報解析研究部

  1. Yasuaki Hayashino, Takuro Shimbo, Satoru Tsujii, Hitoshi Ishii, Hirokazu Kondo, Tsukasa Nakamura, Shizuko Nagata-Kobayashi and Tsuguya Fukui. Cost-effectiveness of coronary artery disease screening in asymptomatic patients with type 2 diabetes and other atherogenic risk factors in Japan: Factors influencing on international application of evidence-based guidelines. Int J Cardiol 118:88-96,2007
  2. Tokuda Y, Takahashi O, Ohde S, Shakudo M, Yanai H, Shimbo T, Fukuhara S, Hinohara S, Fukui T. Gastrointestinal symptoms in a Japanese population: A health diary study. World J Gastroenterol 13:572-578,2007
  3. Shizuko Nagata-Kobayashi, Hiroshi Koyama, Takuro Shimbo. A call for students’ maternity leave in the medical educational system. Med Educ 41:427-428,2007
  4. Tokuda Y, Takahashi O, Ohde S, Ogata H, Yanai H, Shimbo T, Fukuhara S, Hinohara S, Fukui T. Health locus of control and use of conventional and alternative care: a cohort study. Br J Gen Pract 57:643-649,2007
  5. Goto M, Kawamura T, Shimbo T, Takahashi O, Ando M, Miyaki K, Nohara T, Watanabe H, Suzuki I, Aono M; Great Cold Investigators-II. Influence of loxoprofen use on recovery from naturally acquired upper respiratory tract infections: a randomized controlled trial. Intern Med 46:1179-1186,2007
  6. Tokuda Y, Ohde S, Takahashi O, Shakudo M, Yanai H, Shimbo T, Fukuhara S, Hinohara S, Fukui T. Musculoskeletal pain in Japan: prospective health diary study. Rheumatol Int 28:7-14,2007
  7. Yasuharu Tokuda, Sachiko Ohde, Osamu Takahashi, Masaaki Shakudo, Haruo Yanai, Takuro Shimbo, Shunichi Fukuhara, Shigeaki Hinohara, Tsuguya Fukui　Influence of Socioeconomic Factors on Symptom-Related Access to Health Care. Primary Care Japan 5:12-21,2007
  8. Takahashi Y, Miyaki K, Nakayama T. Analysis of news of the Japanese asbestos panic: a supposedly resolved issue that turned out to be a time bomb. J Public Health  29:62-9,2007
  9. Matsuo Y, Takayama K, Nagata Y, Kunieda E, Tateoka K, Ishizuka N, Mizowaki T, Norihisa Y, Sakamoto M, Narita Y, Ishikura S, Hiraoka M. Interinstitutional variations in planning for stereotactic body radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 68:416-425,2007
  10. Honda M, Yogi A, Ishizuka N, Genka I, Gatanaga H, Teruya K, Tachikawa N, Kikuchi Y, Oka S. Effectiveness of Subcutaneous Growth Hormone in HIV-1 Patients with Moderate to Severe Facial Lipoatrophy. Intern Med 46:359-362,2007
  11. Yano H, Saito Y, Takeshita E, Miyake O, Ishizuka N.  Prediction of lateral pelvic node involvement in low rectal cancer by conventional computed tomography.　Br J Surg 94:1014-1019,2007
  12. Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A; JCARE-GENERAL Investigators. Characteristics and outcomes of patients with heart failure in general practices and hospitals. Circ J 71:449-54,2007.

細胞組織再生医学研究部

  1. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R, Sharov AA, Ko MS, Niwa H. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.  Nat Cell Biol 9: 625-35, 2007
  2. Osada A, Iwabuchi T, Kishimoto J, Hamazaki TS, Okochi H. Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction. Tissue Eng 13: 975-982, 2007
  3. Nakanishi M, Hamazaki TS, Komazaki S, Okochi H, Asashima M. Pancreatic tissue formation from murine embryonic stem cells in vitro. Differentiation 75: 1-11, 2007
  4. Ito Y, Hamazaki TS, Ohnuma K, Tamaki K, Asashima M, Okochi H. Isolation of murine hair-inducing cells using the cell surface marker prominin-1/CD133. J Invest Dermatol 127: 1052-1060, 2007
  5. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, Okochi H, Ochiya T.   Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes.  Hepatology 46: 219-228, 2007
  6. Kaburagi Y, Okochi H, Satoh S, Yamashita R, Hamada K, Ikari K, Yamamoto-Honda R, Terauchi Y, Yasuda K, Noda M. Role of IRS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins.  Cell Struct Funct 32: 69-78, 2007
  7. Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K. Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.  Mol Biol Cell 18: 1421-1429, 2007
  8. Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.  Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.  Dev Cell 12: 129-141, 2007
  9. Kuwano Y, Fujimoto M, Watanabe R, Asashima N, Nakashima H, Ohno H, Yano S, Yazawa N, Okochi H, Tamaki K. Serum anti-Fc gamma receptor autoantibodies in patients with alopecia areata. Arch Dermatol Res 298: 493-498, 2007
  10. Watanabe R, Ishiura N, Nakashima H, Yazawa N, Kuwano Y, Tada Y, Okochi H, Fujimoto M, Tamaki K. Increased serum levels of circulating CD40 ligand in patients with bullous
    pemphigoid: preliminary results.  Dermatology 215: 180-186, 2007
  11. Kuwano Y, Prazma CM, Yazawa N, Watanabe R, Ishiura N, Kumanogoh A, Okochi H, Tamaki K, Fujimoto M, Tedder TF. CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.  Int Immunol 19: 977-992, 2007
  12. Kuwano Y, Fujimoto M, Watanabe R, Ishiura N, Nakashima H, Komine M, Hamazaki TS, Tamaki K, Okochi H. The involvement of Gab1 and PI 3-kinase in beta1 integrin signaling in keratinocytes.  Biochem Biophys Res Commun 14; 361: 224-229, 2007
  13. Watanabe R, Fujimoto M, Ishiura N, Kuwano Y, Nakashima H, Yazawa N, Okochi H, Sato S, Tedder TF, Tamaki K.  CD19 expression in B cells is important for suppression of contact hypersensitivity.  Am J Pathol 171: 560-570, 2007
  14. Kuwano Y, Fujimoto M, Watanabe R, Ishiura N, Nakashima H, Ohno Y, Yano S, Yazawa N, Okochi H, Tamaki K. Serum chemokine profiles in patients with alopecia areata. Br J Dermatol 157: 466-473, 2007
  15. Nakashima H, Fujimoto M, Asashima N, Watanabe R, Kuwano Y, Yazawa N,  Maruyama N, Okochi H, Kumanogoh A, Tamaki K. Serum chemokine profile in patients with bullous pemphigoid. Br J Dermatol 156: 454-459, 2007
  16. Watanabe R, Fujimoto M, Yazawa N, Nakashima H, Asashima N, Kuwano Y, Tada Y, Maruyama N, Okochi H, Tamaki K. Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid. J Dermatol Sci 46: 53-60, 2007

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