（2010年1月1日以降）

副所長室

  1. Fujioka K, Tomizawa Y, Yamamoto K., Manome Y. Numerical coversation of smell fromfrozen food and its variation with temperature. Japanese Journal of Taste Smell Research 17(3):533-536, 2010.
  2. Kato S, Itoh K, Yaoi T, Tozawa T, Yoshikawa Y, Yasui H, Kanamura N, Hoshino A, Manabe N, Yamamoto K, Fushiki S. Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain. Nanotechnology 21(33):335103, 2010.
  3. Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K.Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts. J. Biol. Chem 285(37):28826-28837, 2010.
  4. Osaki Y, Maehara Y, Sato M, Hoshino A, Yamamoto K, Nagao T, Suzuki K, Kawachi S. Analysis of cytokine chemokine levels in bronchoalveolar lavage fluids from patients with acute respiratory distress syndrome. Journal of the Japansese Society of Intensive Care Medicine 17(2):179-184, 2010
  5. Fujioka K, Manabe N, Nomura M, Watanabe M, Takeyama H, Hoshino A, Hanada S, Yamamoto K., Manome Y. Detection of thyroid carcinoma antigen with Quantum dots and monoclonal IgM antibody (JT-95) systems. J. Nanomater 2010:Article ID:937684 (7 pages). 2010 (2010),
  6. Yamamoto S, Manabe N, Yamamoto K. High-Definition Slit Lamp Video Camera System. Ophthalmic Surgery Lasers & Imaging41(2).2010.
  7. Prabakar S, Shiohara A, Hanada S, Fujioka K, Yamamoto K,Tilley RD. Size Controlled Synthesis of Germanium Nanocrystals with Hydride Reducing Agents and their Biological Applications. Chemistry of Materials 22(2), pp482-486, 2010.
  8. Shiohara A, Hanada S, Prabakar S, Fujioka K, Lim TH, Yamamoto K, Northcote PT, Tilley RD. Chemical Reactions On Surface Molecules Attached to Silicon Quantum Dots J Am Chem Soc. 132(1):248-253,2010.

熱帯医学・マラリア研究部

  1. Kawazu S, Takemae H, Komaki-Yasuda K, Kano S. Target proteins of the cytosolic thioredoxin in Plasmodium falciparum. Parasitol Int 59: 298-302, 2010.
  2. Hoshino S, Konishi M, Mori M, Shimura M, Nishitani C, Kuroki Y, Koyanagi Y, Kano S, Itabe H, Ishizaka Y. HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. J Leukoc Biol 87(6): 1133-1143, 2010.
  3. Shigeyuki Kano. Artemisinin-based combination therapies and their introduction in Japan. J Infect Chemother 16(6): 375-382, 2010.
  4. Iwagami M, Hwang SY, Fukumoto M, Hayakawa T, Tanabe K, Kim SH, Kho WG, Kano S. Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome. Malaria J 9: 184-188, 2010.
  5. Wilairatana P, Tangpukdee N, Kano S, Krudsood S. Primaquine administration after falciparum malaria treatment in malaria hypoendemic areas with high incidence of falciparum and vivax mixed infection: pros and cons. Korean J Parasitol 48(2):175-177. Epub Jun 17,2010.
  6. Wattana Leowattana, Noppadon Tangpukdee, Sai Kaung Thar, Souwanit Nakasiri, Siripun Srivilairit, Shigeyuki Kano, Polrat Wilairatana, Srivicha Krudsood: Changes in platelet count in uncomplicated and severe falciparum malaria. Southeast Asian J Trop Med Public Health 41(5): 1035-1041, 2010.
  7. Yasutaka Mizuno, Koichiro Kudo, Shigeyuki Kano: Mefloquine chemoprophylaxis against malaria in Japanese travelers: results of a study on adverse effects. Trop Med Health 38(3): 103-106, 2010.
  8. Polrat Wilairatana, Noppadon Tangpukdee, Sant Muangnoicharoen, Srivicha Krudsood, Shigeyuki Kano: Atypical lymphocytes in malaria mimicking dengue infection in Thailand. Res Report Trop Med 1: 37-43, 2010.
  9. Noppadon Tangpukdee, Khim Myat Wai, Sant Muangnoicharoen, Shigeyuki Kano, Nanthaporn Phophak, Janram Tiemprasert, Srivicha Krudsood, Polrat Wilairatana: Indicators of fatal outcome in severe Plasmodium falciparum malaria: a study in a tertiary-care hospital in Thailand. Asian Pacific J Trop Med: 855-859, 2010.
  10. Noriyuki Okudaira, Kenta Iijima, Takayoshi Koyama, Yuzuru Minemoto, Shigeyuki Kano, Akio Mimori, Yukihito Ishizaka: Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b] carbazole (FICZ), a tryptophan photoproduct. Proc Natl Acad Sci USA. 107(43): 18487-18492, Oct 26,2010.
  11. Daisuke Nonaka, Sakhone Laimanivong, Jun Kobayashi, Keobouphaphone Chindavonsa, Shigeyuki Kano, Viengxay Vanisaveth, Junko Yasuoka, Samlane Phompida, Masamine Jimba: Is staying overnight in a farming hut a risk factor for malaria infection in a setting with insecticide-treated bed nets in rural Laos? Malaria J 9:372, 2010.
  12. Yutaka Midorikawa, Kaoru Midorikawa, Bounphenh Sangsomsack, Trykhouane Phoutavane, Kanpheng Choumlasack, Toru Watanabe, Nanthasane Vannavong, Shigehisa Habe, Nakatsu Masami, Yasuyuki Kosaka, Kongsap Akkhavong, Michel Strobel, Boungnong Boupha, Satoshi Nakamura: Water, livelihood and health in Attopeu province in Lao PDR. Southeast Asian Studies 47(4): 478-498, 2010
  13. Yutaka Midorikawa, Satoshi Nakamura, Rattanaphone Phetsouvanh, Manivanh Vongsouvaht, Kaoru Midorikawa: Detection of non-typhoid Salmonella infection by citrus and citrus extracts in Lao PDR. Asian Pacific J Trop Med 3(12): 939-942, 2010.
  14. Shigeyuki Kano: Social technology development by community participatory approaches for the control of malaria in Palawan island, the Philippines. Education for Sustainable Development (ESD) on Infectious Diseases and Global Environmental Issues. ed by Organizing Committiee of OASERD (Obihiro Asia and the Pacific Seminar on Education for Rural Development), Dairy Japan Co. Ltd, Tokyo, Japan (ISBN: 978-4-924506-55-8), pp75-83, 2010.

呼吸器疾患研究部

  1. Matsuyama M, Miura Y, Kiwamoto T, Moriya A, Kokuho N, Shimizu K, Otsuka S, Hijikata M, Keicho N, Hayashihara K, Saito T. A case of familial pulmonary Mycobacterium avium complex disease. Internal Med 49 (10): 949-53, 2010.
  2. Ridruechai C, Mahasirimongkol S, Promjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Chuchotaworn C, Manosuthi W, Kantipong P, Sawanpanyalert P, Keicho N, Khusmith S, Tokunaga K. Association analysis of candidate regions on chromosome 5q31 for tuberculosis. Genes Immun 11: 416-22, 2010.
  3. Hijikata M, Matsushita I, Tanaka G, Tsuchiya T, Ito H, Tokunaga K, Ohashi J, Homma S, Kobashi Y, Taguchi Y, Azuma A, Kudoh S, Keicho N. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. Hum Genet 29 ((2)): 117-28, 2011.
  4. Tanaka T, Sakurada S, Kano K, Takahashi E, Yasuda K, Hirano H, Kaburagi Y, Kobayashi N, Hang N, Lien L, Matsushita I, Hijikata M, Uchida T, Keicho N. Identification of tuberculosis-associated proteins in whole blood supernatant. BMC Infect Dis.;11 (1): 71, 2011.
  5. Sherchand JB. Ohara H. Sherpa K, Sakurada S, Grung B. Tandukar S. Pradhan l. Burlakoti T. Pokharel BM. Sherchgand JB. Rotavirus nosocomial infection in children under 5 years of age: a preliminary study in Nepal. J. Nepal Paediatr. Soc.:31(1): 30.2011
  6. Keicho N, Hijikata M. Genetic predisposition to diffuse panbronchiolitis. Respirology,Feb 9. doi: 10.1111/j.1440-1843.2011.01946.x.

感染症制御研究部

  1. Ando H, Mitarai S, Kondo Y, Suetake T, Sekiguchi J, Kato S, Mori T, Kirikae T: Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan. Clin Microbiol Infect 54:1793-1799, 2010.
  2. Miyoshi-Akiyama T, Narahara K, Mori S, Kitajima H, Kase T, Morikawa S, Kirikae T: Development of an immunochromatographic assay specifically detecting pandemic H1N1 (2009) influenza virus. J Clin Microbiol 48:703-708. 2010.
  3. Watanabe-Takahashi M, Sato T, Dohi T, Noguchi N, Kano F, Murata M, Hamabata T, Natori Y, Nishikawa K: An orally applicable Shiga toxin-neutralizer functions in the intestine to inhibit the intracellular transport of the toxin. Infect Immun 78: 177-183, 2010.
  4. Sabui S, Ghosal A, Dutta S, Ghosh A, Ramamurthy T, Nataro JP, Hamabata T, Chatterjee NS: Allelic variation in colonization factor CS6 of enterotoxigenic Escherichia coli isolated from acute diarrhoeal patients and controls. J Med Microbiol 59:770-779, 2010.
  5. Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y: TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res 85: 551-555, 2010.
  6. Kitao T, Miyoshi-Akiyama T, Shimada K, Tanaka M, Narahara K, Saito N, Kirikae T: Development of an immunochromatographic assay for the rapid detection of AAC(6')-Iae-producing multidrug-resistant Pseudomonas aeruginosa. J Antimicrob Chemother 65:1382-1386, 2010.
  7. Ohara-Imaizumi M, Yoshida M, Aoyagi K, Saito T, Okamura T, Takenaka H, Akimoto Y, Nakamichi Y, Takanashi-Yanobu R, Nishiwaki C, Kawakami H, Kato N, Hisanaga S, Kakei M, Nagamatsu S: Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. PLoS One 5, e15553, 2010.
  8. Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, Shirasawa S: Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Proc Natl Acad Sci U S A 107: 14199-14204, 2010.
  9. Senoh M, Ghosh-Banerjee J, Ramamurthy T, Hamabata T, Kurakawa T, Takeda M, Colwell RR, Nair GB, Takeda Y. Conversion of viable but nonculturable Vibrio cholerae to the culturable state by co-culture with eukaryotic cells. Microbiol Immunol 54: 502-507, 2010.
  10. Ghosh-Banerjee J, Senoh M, Takahashi T, Hamabata T, Barman S, Koley H, Mukhopadhyay AK, Ramamurthy T, Chatterjee S, Asakura M, Yamasaki S, Nair GB, Takeda Y: Cholera toxin production by El Tor variant of Vibrio cholerae O1 as compared to prototype El Tor and classical biotypes. J Clin Microbiol 48: 4283-4286, 2010.
  11. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N: The solute carrier family15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. *These authors equally contributed to this work., Gastroenterology, Gastroenterology, 140:1513-1525, 2011.
  12. Ando H, Kitao T, Miyoshi-Akiyama T, Kato S, Mori T, Kirikae T: Down-regulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol 79:1615-1628, 2011.
  13. Hanaki K, Sekiguchi J, Shimada K, Sato A, Watari H, Kojima T, Miyoshi-Akiyama T, Kirikae, T: Loop-mediated isothermal amplification assays for identification of antiseptic- and methicillin-resistant Staphylococcus aureus. J Microbiological Methods 84:251-254, 2011.
  14. Kawachi S, Matsushita T, Sato T, Nunoi H, Noguchi H, Ota S, Kanemoto N, Nakatani K, Nishiguchi T, Yuge A, Imamura H, Kitajima H, Narahara K, Suzuki K, Miyoshi-Akiyama T, Kirikae T: Multicenter prospective evaluation of a novel rapid immunochromatographic diagnostic kit specifically detecting influenza A H1N1 2009 virus. J Clin Virol 51:68-72, 2011.
  15. Ando, H. Mitarai S, Kondo Y, Suetake T, Kato S, Mori T, Kirikae T.: Evaluation of a line probe assay for rapid detection of gyrA mutations associated with fluoroquinolone resistance in multidrug-resistant Mycobacterium tuberculosis. J Med Microbiol 60:184-188, 2011.
  16. Shimomura Y, Okumura K, Yamagata Murayama S, Yagi J, Ubukata K, Kirikae T, Miyoshi-Akiyama T: Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). BMC Genomics 12: 17, 2011.
  17. Miyoshi-Akiyama T, Ishida I, Fukushi M, Yamaguchi K, Matsuoka Y, Ishihara T, Tsukahara M, Hatakeyama S, Itoh N, Morisawa A, Yoshinaka Y, Yamamoto N, Lianfeng Z, Chuan Q, Kirikae T, Sasazuki T: Fully human monoclonal antibody directed to proteolytic cleavage site in SARS coronavirus S protein neutralizes the virus in a Rhesus macaque SARS model. J Infect Dis, in press
  18. Miyoshi Y, Hamase K, Okamura T, Konno R, Kasai N, Tojo Y, Zaitsu, K: Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acidoxidase. J Chromatogr B Analyt Technol Biomed Life Sci, in press
  19. Shinya K, Okamura T, Sueta S, Kasai N, Tanaka M, Ginting TE, Makino A, Eisfeld AJ, Kawaoka Y: Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses. Virol J, in press
  20. Matsui T, Takita E, Sato T, Aizawa M, Ki M, Kadoyama Y, Hirano K, Kinjo S, Asao H, Kawamoto K, Kariya H, Makino S-I, Hamabata T, Sawada K, Kato K: Production of double repeated B subunit of Shiga toxin 2e at high levels in transgenic lettuce plants as vaccine material for porcine edema disease. Transgenic Res, in press.

疾患制御研究部

  1. Gokoh M, Nakamura N, Matsuyama S, Nishio M, Akutsu H, Umezawa A, Yasuda K, Yuo A, Saeki K: Early senescence is not an inevitable fate of human induced pluripotent stem-derived cells. Cellular Reprogramming (in press)
  2. Saeki K. A Feeder-Free Culture Method for the High Efficiency Production of Subculturable Vascular Endothelial Cells from Human Embryonic Stem Cells. Lineage-Specific Differentiation of Human Embryonic and Induced Pluripotent Stem Cells Methods and Protocol (Chapter 20)　 edited by Kaiming Ye; Sha Jin; Heather Tanner. Springer Protocols Handbook series, Humana Press, Springer Science and Business, LLC, USA (in press)

難治性疾患研究部

  1. Takahashi Y, Haga S, Ishizaka Y, Mimori A. (H.S; Equal contributors) Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases. Arthritis Research & Therapy, 12:R85-R92, 2010.
  2. Hoshino S, Konishi M, Mori M, Shimura M, Nishitani C, Kuroki Y, Koyanagi Y, Kano S, Itabe H, Ishizaka Y. HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. J Leukoc Biol. 87:1133-1143.2010.
  3. Okudaira N, Iijima K, Koyama T, Minemoto Y, Kano S, Mimori A, Ishizaka Y. Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct. Proc Natl Acad Sci U S A. 107:18487-18492, 2010.
  4. Matsuyama S, Shimura M, Fujii M, Maeshima K, Yumoto H, Mimura H, Sano Y, Yabashi M, Nishino Y, Tamasaku K, Ishizaka Y, Ishikawa T, Yamauchi K, Elemental mapping of frozen hydrated cells with cryo-scanning X-ray fluorescence microscopy. X-Ray Spectrometry 39: 260-266, 2010.
  5. Iwabu, Y., Kinomoto, M., Tatsumi, M., Fujita, H., Shimura, M., Tanaka, Y., Ishizaka, Y., Nolan, D., Mallal, S., Sata, T., Tokunaga, K. Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes. J Biol Chem., 285:35350-35358, 2010.
  6. Kono, K., Ozawa, T., Yoshida, T., Ozaki, F., Ishizaka, Y., Maruyama, K., Kojima, C., Harada, A., Aoshima, S. Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy. Biomaterials, 31(27):7096-105, 2010.
  7. Kono, K., Nakashima, S., Kokuryo, D., Aoki, I., Shimomoto, H., Aoshima, S., Maruyama, K., Yuba, E., Kojima, C., Harada, A., Ishizaka, Y. Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy. Biomaterials 32(): 1387-1395, 2011.
  8. Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010Mar;85(3):551-5.
  9. Sanae Uchida, Nobumoto Watanabe, Yasusei Kudo, Katsuji Yoshioka, Tsukasa Matsunaga, Yukihito Ishizaka, Hitoshi Nakagama, Randy Y.C. Poon, and Katsumi Yamashita. SCFβTrCP mediates stress-activated MAP kinase-induced Cdc25B degradation. J. Cell Sci. in press.
  10. Daiki Taneichi, Kenta Iijima, Akihiro Doi, Takayoshi Koyama, Yuzuru Minemoto, Kenzo Tokunaga, Mari Shimura, Yukihito Ishizaka. Identification of SNF2h, a Chromatin-Remodeling Factor, as a Novel Binding Protein of Vpr of Human Immunodeficiency Virus Type 1. J. Neuroimmune Pharmacol. In press.

遺伝子診断治療開発研究部

  1. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N*. Blood pressure and hypertension are associated with seven loci showing male-specific interaction with age among the Japanese. Circulation. 121(21):2302-9, 2010.
  2. Takeuchi F, Kashida M, Okazaki O, Tanaka Y, Fukuda S, Kashima T, Hosaka S, Hiroe M, Kimura S, Kato N. Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients. Circ J. 74(5):977-82,2010.
  3. Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato N*, Yanai K*. Identification and characterization of glucocorticoid receptor-binding sites in the human genome. J Recept Signal Transduct Res. 30(2):88-105,2010.
  4. Takeuchi F, Katsuya T, Charkrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N*. Common variants at the GCK, GCKR, G6PC2-ABCB11, and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia. 53(2):299-308,2010.
  5. Ohara-Imaizumi M, Yoshida M, Aoyagi K, Saito T, Okamura T, Takenaka H, Akimoto Y, Nakamichi Y, Takanashi-Yanobu R, Nishiwaki C, Kawakami H, Kato N, Hisanaga S, Kakei M, Nagamatsu S. Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. PLoS One. 2010 Dec 9;5(12):e15553
  6. S. Jesmin, S. Gando. Letter to the Editor, SHOCK, 33(3):339-340, 2010.
  7. S. Jesmin, CN. Mowa, S. Sultana, S. Mia, R. Islam, S. Zaedi, I. Sakuma, Y. Hattori, M. Hiroe, N. Yamaguchi. Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice. Biomed Res. 31(6):337-46, 2010.
  8. S. Jesmin, CN. Mowa, S. Sultana, N. Shimojo, H. Togashi, Y. Iwashima, N. Kato, A. Sato, I. Sakuma, M. Hiroe, Y. Hattori, N. Yamaguchi, H. Kobayashi. VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha. Eur J Pharmacol. 1;641(2-3):168-78, 2010.
  9. N. Yamaguchi, S. Jesmin, A. Koyama. Hematuria. The Journal of Practical Pharmacology, 61(4): 204-207, 2010.
  10. Dassanayake AS, Kasturiratne A, Niriella MA, Kalubovila U, Rajindrajith S, De Silva AP, Kato N, Wickremasinghe R and de Silva J. Prevalence of acanthosis nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome. BMC Research Notes. 4(1):25,2011.
  11. Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N. Confirmation of ALDH2 as a major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in Japanese. Circ J. 75(4):911-8,2011.
  12. S. Jesmin, S. Sultana, SH. Prodhan, N. Yamaguchi, S. Zaedi, A. Sawamura, Y. Iwashima, S. Gando. Time-dependent expression of endothelin-1 in lungs and the effects of TNF-α blocking peptide on endothelin-1 levels in lungs in endotoxemic rat model. Biomed Res. 32(1):9-17, 2011.
  13. S. Jesmin, S. Zaedi, AM. Islam, SN. Sultana, Y. Iwashima, T. Wada, N. Yamaguchi, M. Hiroe, S. Gando. Time-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis. Inflammation. [Epub ahead of print] 2011 Apr 29.
  14. Takeuchi F*, Kobayashi S, Ogihara T, Fujioka A, Kato N. Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants. Genome Res. 2011 Mar 25. [Epub ahead of print]
  15. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, Ikegami H, Nakamura J, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Takayanagi R, Kato N. Association of obesity susceptibility genetic variants with type 2 diabetes in the Japanese. Diabetologia. Mar 3. [Epub ahead of print]
  16. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N. The solute carrier family15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology. Jan 26. [Epub ahead of print]

細胞組織再生医学研究部

  1. Kajiyama H, Hamazaki TS, Tokuhara M, Masui S, Okabayashi K, Ohnuma K, Yabe S, Yasuda K, Ishiura S, Okochi H, Asashima M. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.　 Int J Dev Biol. 54:699-705, 2010.
  2. Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M. Differential Phosphorylation of Functional Tyrosines in CD19 Modulates B Lymphocyte Activation. Eur J Immunol. 40:1192-1204, 2010.
  3. Nakashima H, Hamaguchi Y, Watanabe R, Ishiura N, Kuwano Y, Okochi H, Takahashi Y, Tamaki K, Sato S, Tedder TF, Fujimoto M. CD22 Expression Mediates the Regulatory Functions of Peritoneal B-1a Cells during the Remission Phase of Contact Hypersensitivity Reactions.　 J Immunol. 184:4637-4645, 2010.
  4. Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, Fujimoto M, Tedder TF. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.　 J Immunol. 184:4789-800, 2010.
    5. "
  5. Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol. 184:4801-9, 2010.
    6. "
  6. Masui S.　 Pluripotency maintenance mechanism of embryonic stem cells and reprogramming.　　 Int J Hematol.　 91:360-72, 2010.
  7. Wakabayashi M, Ito Y, Hamazaki TS, Okochi H. Efficient Myogenic Differentiation of Murine Dermal Sca-1 (–) Cells via Initial Aggregation Culture. Tissue Eng PartA 16:3251-9. 2010.
  8. Konno M, Hamazaki TS, Fukuda S, Tokuhara M, Uchiyama H, Okazawa H, Asashima M, Okochi H. Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture. Biochem Biophys Res Commun. 400:461-5, 2010.
  9. Miyagaki T, Sugaya M, Murakami T, Asano Y, TadaY, Kadono T, Okochi H, Tamaki K, Sato S. CCL11-CCR3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation. Cancer Res 71:2056-65, 2011.

消化器疾患研究部

  1. Watanabe-Takahashi M, Sato T, Dohi T, Noguchi N, Kano F, Murata M, Hamabata T, Natori Y, Nishikawa K. An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin. Infect Immun. 78:177-183,2010.
  2. Sasawatari S, Yoshizaki M, Taya C, Furuyama-Tanaka K., Yonekawa H, Dohi T, Makrigiannis A P, Sasazuki T, Inaba K., Toyama-Sorimachi N*. Ly49Q plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.　 Immunity, 32(2): 200-213, 2010.
  3. Hayashi M, Nakashima T, Kodama T, Makrigiannis AP, Toyama-Sorimachi N, Takayanagi H*.　Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Biochem Biophys Res Com, 393(3): 432-438, 2010.
  4. Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H*.　Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.　J Clin Invest, [Epub ahead of print] Jul 1. pii: 40658. doi: 10.1172/JCI40658, 2010.
  5. Burkly LC, Dohi T. The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse. Adv Exp Med Biol. 691:305-322,2011.
  6. Hata S, Abe M, Suzuki H, Kitamura F, Toyama-Sorimachi N, Abe K., Sakimura K., and Sorimachi*, H. Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genetics, in press

免疫制御研究部

  1. Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, *Takaki S, *Eto K. [*corresponding author] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo. J Clin Invest 120: 179-190, 2010.
  2. Larson RP, Zimmerli SC, Comeau MR, Itano A, Omori M, Iseki M, Hauser C, Ziegler SF. Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. J Immunol 184: 2974-2984, 2010.
  3. Kamei N, Kwon SM, Alev C, Ishikawa M, Yokoyama A, Nakanishi K, Yamada K, Horii M, Nishimura H, Takaki S, Kawamoto A, Ii M, Akimaru H, Tanaka N, Nishikawa SI, Ochi M, Asahara T. Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury. Stem Cells 28: 365-375, 2010.
  4. Matsumoto T, Ii M, Nishimura H, Shoji T, Mifune Y, Kawamoto A, Kuroda R, Fukui T, Kawakami Y, Kuroda T, Kwon SM, Iwasaki H, Horii M, Yokoyama A, Oyamada A, Lee SY, Hayashi S, Kurosaka M, Takaki S, Asahara T. Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. J Exp Med. 207: 2207-2223, 2010.

代謝疾患研究部

  1. Takarabe D, Rokukawa Y, Takahashi Y, Goto A, Takaichi M, Okamoto M, Tsujimoto T, Noto H, Kishimoto M, Kaburagi Y, Yasuda K, Yamamoto-Honda R, Tsukada K, Honda M, Teruya K, Kajio H, Kikuchi Y, Oka S, Noda M. Autoimmune diabetes in HIV-infected patients on highly active antiretroviral therapy. J Clin Endocr Metab. 95(8): 4056-60, 2010.
  2. Hiramoto M, Maekawa N, Kuge T, Ayabe F, Watanabe A, Masaike Y, Hatakeyama M. Handa H, Imai T. High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads. Biomed Chromatogr. 24(6):606-12, 2010.
  3. Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 53:115-22, 2010.
  4. Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandvaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am J Hum Genet 86(1): 54-64, 2010.
  5. Kajiyama H, Hamazaki TS, Tokuhara M, Masui S, Okabayashi K, Ohnuma K, Yabe S, Yasuda K, Ishiura S, Okochi H, Asashima M. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol 54(4): 699-705, 2010.
  6. Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Graup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jorgensen T, Lauritzen T, Sandbaek A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So W-Y, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwagi A, Kawamori R, Kasuga M, Froguel P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics, 42(10):864-8, 2010.
  7. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 123: 2792-802, 2010.
  8. Tanaka T, Sakurada S, Kano K, Takahashi E, Yasuda K, Hirano H, Kaburagi Y, Kobayashi N, Hang NTL, Lien LT, Matsushita I, Hijikata M, Uchida Y, Keicho N. Identification of tuberculosis-associated proteins in whole blood supernatant. BMC Infectious Diseases 11: 71, 2011.
  9. Tsujimoto T, Takaichi M, Endo H, Yasuda K, Kishimoto M, Noto H, Gomibuchi H, Yasuda H, Yamamoto-Honda R, Takahashi Y, Kajio H, Sasano H, Noda M. A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a Brenner tumor. Am J Med Sci 341(1): 74-77, 2011.
  10. Maekawa N, Hiramoto M, Sakamoto S, Azuma M, Ikeda M, Naitou M, Acharya HP, Kobayashi Y, Suematsu M, Handa H, Imai T. High performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads. Biomed Chromatogr. 2010, in press.
  11. Kaburagi Y, Yamashita R, Takahashi E, Yasuda K, Noda M. Proteomic studies on investigations of diabetes. J Mass Spectrom Soc Jpn, in press

分子代謝制御研究部

  1. Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. Ablation of C/EBPb alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest. 120(1):115-26. 2010.
  2. Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S Jr, Itoh H, Noda T, Kasuga M, Nakae J. PDK1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J physiol Endocrinol Metab. 298(4): E787-98, 2010.

臓器障害研究部

  1. Takarabe D, Rokukawa Y, Takahashi Y, Goto A, Takaichi M, Okamoto M, Tsujimoto T, Noto H, Kishimoto M, Kaburagi Y, Yasuda K, Yamamoto-Honda R, Tsukada K, Honda M, Teruya K, Kajio H, Kikuchi Y, Oka S, Noda M. Autoimmune diabetes in HIV-infected patients on highly active antiretroviral therapy. J Clin Endocrinol Metab. 95:4056-4060,2010.
  2. Tanaka T, Sakurada S, Kano K, Takahashi E, Yasuda K, Hirano H, Kaburagi Y, Kobayashi N, Le Hang NT, Lien LT, Matsushita I, Hijikata M, Uchida T, Keicho N. Identification of tuberculosis-associated proteins in whole blood supernatant. BMC Infect Dis. in press

糖尿病研究部

  1. Nagasawa T, Noda M, Katagiri S, Takaichi M, Takahashi Y, Wara-Aswapati N, Kobayashi H, Ohara S, Kawaguchi Y, Tagami T, Furuichi Y, Izumi Y: Relationship between periodontitis and diabetes — Importance of a clinical study to prove the vicious cycle.Intern Med 49: 881-885, 2010.
  2. Noda M, Mizoue T: Relation between Dietary Calcium and Vitamin D and Risk of Diabetes and Cancer: a Review and Perspective. J Clin Metab Diabetes 1: 55-60, 2010.
  3. Nanri A, Mizoue T, Takahashi Y, Noda M, Inoue M, Tsugane S; Japan Public Health Center- based Prospective Study Group:Weight change and all-cause, cancer and cardiovascular disease mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study. Int J Obes 34: 348-356, 2010.
  4. Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T: Decreased insulin secretion and accumulation of triglyceride in b cells overexpressing a dominant-negative form of AMP-activated protein kinase. Endocr J 57: 141-152, 2010.
  5. Nanri A, Mizoue T, Takahashi Y, Kirii K, Inoue M, Noda M, Tsugane S: Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women. J Nutr 140: 580-586, 2010.
  6. Goto A, Takaichi M, Kishimoto M, Takahashi Y, Kajio H, Shimbo T, Noda M: Body mass index, fasting plasma glucose levels, and C-peptide levels as predictors of the future insulin use in Japanese type 2 diabetic patients. Endocr J 57: 237-244, 2010.
  7. Noda M, Kato M, Takahashi Y, Matsushita Y, Mizoue T, Inoue M, Tsugane S, Kadowaki T: Fasting plasma glucose and 5-year incidence of diabetes in the JPHC Diabetes Study — suggestion for the threshold for impaired fasting glucose among Japanese. Endocr J 57: 631-639, 2010.
  8. Kimura S, Satoh T, Ikeda S, Noda M, Nakayama T: Development of a database of health insurance claims: standardization of disease classifications and anonymous record linkage. J Epidemiol 20: 413-419, 2010.
  9. Takarabe D, Rokukawa Y, Takahashi Y, Goto A, Takaichi M, Okamoto M, Tsujimoto T, Noto H, Kishimoto M, Kaburagi Y, Yasuda K, Yamamoto-Honda R, Tsukada K, Honda M, Teruya K, Kajio H, Kikuchi Y, Oka S, Noda M: Autoimmune diabetes in HIV-infected patients on highly active antiretroviral therapy. J Clin Endocrinol Metab 95: 4056-4060, 2010.
  10. Matsushita Y, Nakagawa T, Yamamoto S, Takahashi Y, Yokoyama T, Noda M, Mizoue T: Associations of visceral and subcutaneous fat areas with the prevalence of metabolic risk factor clustering in 6292 Japanese individuals: the Hitachi Health Study. Diabetes Care 33: 2117–2119, 2010
  11. Kishimoto M, Endo H, Hagiwara S, Miwa A, Noda M: Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report. J Med Invest 57: 345-349, 2010.
  12. Nanri A, Mizoue T, Noda M, Takahashi Y, Inoue M, Kirii K, Tsugane S, for the Japan Public Health Center-based Prospective Study Group: Magnesium intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-Based Prospective Study. Eur J Clin Nutr 64: 1244-1247, 2010.
  13. Noto H, Osame K, Sasazuki T, Noda M: Substantially increased risk of cancer in patients with diabetes mellitus. A systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications 24: 345–353, 2010.
  14. Nanri A, Mizoue T, Noda M, Takahashi Y, Kato M, Inoue M, Tsugane S for the Japan Public Health Center-based Prospective Study Group: Rice intake and type 2 diabetes in Japanese men and women: Japan Public Health Center-based Prospective Study. Am J Clin Nutr 92: 1468-1477, 2010.
  15. Izumi K, Hayashino Y, Yamazaki K, Suzuki H, Ishizuka N, Kobayashi M, Noda M: The J-DOIT2 Study Group: Multifaceted intervention to promote the regular visit of patients with diabetes to primary care physicians: - rationale, design, and conduct of a cluster randomized controlled trial - the Japan Diabetes Outcome Intervention Trial 2 (J-DOIT2) Study Protocol. Diabetology Int 1:83–89, 2010.
  16. Nanri A, Mizoue T, Takahashi Y, Matsushita Y, Noda M, Inoue M, Tsugane S, for the Japan Public Health Center-based Prospective Study Group: Association of weight change in different periods of adulthood with risk of type 2 diabetes in Japanese men and women: the Japan Public Health Center-Based Prospective Study. J Epidemiol Community Health : in press, 2010.
  17. Tsujimoto T, Takaichi M, Endo H, Yasuda K, Kishimoto M, Noto H, Gomibuchi H, Yasuda H, Yamamoto-Honda R, Takahashi Y, Kajio H, Sasano H, Noda M: A diabetic patient with breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a Brenner tumor. Am J Med Sci 341: 74-77, 2011.
  18. Poudel-Tandukar K, Nanri A, Iwasaki M, Mizoue T, Matsushita Y, Takahashi Y, Noda M, Inoue M, Tsugane S for the Japan Public Health Center-based Prospective Study Group: Long chain n-3 fatty acids intake, fish consumption and suicide in a prospective cohort of Japanese men and women - The Japan Public Health Center-based (JPHC) Study. J Affect Disord 129: 282-288, 2011.
  19. Goto M, Yamamoto-Honda R, Shimbo T, Goto A, Terauchi Y, Kanazawa Y, Noda M: Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests. Endocr J 58: 13-17, 2011.
  20. Kishimoto M, Sugiyama T, Osame K, Takarabe D, Okamoto M, Noda M: Efficacy of ezetimibe as monotherapy or combination therapy in hypercholesterolemic patients with and without diabetes. J Med Invest 58: 86-94, 2011.
  21. Matsushita Y, Nakagawa T, Yamamoto S, Takahashi Y, Noda M, Mizoue T: Associations of smoking cessation with visceral fat area and prevalence of metabolic syndrome in men: the Hitachi Health Study. Obesity 19: 647-651, 2011.
  22. Yanai H, Yoshimi T, Honda R: Effective switch from twice-daily pre-mixed insulin 50/50 to Liraglutide to achieve a good glycemic control in type 2 diabetes. J Med Cases 2: 76-80, 2011.

分子炎症制御研究プロジェクト

  1. Ishikawa, K., Toyama-Sorimachi, N.*(*corresponding author) , Nakada, K., Morimoto, M., Imanishi, H., Yoshizaki, M., Sasawatari, S., Niikura, M., Takenaga, K., Yonekawa, H., Hayashi, J.-I.* The innate immune system in host mice targets cells with allogenic mitochondrial DNA. J. Exp. Med. 207:2297-2305, 2010.
  2. Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H.*　Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.　J Clin Invest. 120(8):2672-83, 2010.　
  3. Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.* Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genetics 6:e1001040, 2010.
  4. Sasawatari, S., Okamura, T., Kasumi, E., Tanaka-Furuyama, K., Yanobu-Takanashi, R., Shirasawa, S., Kato, N. and Toyama-Sorimachi, N.* The solute carrier family15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology 2011 Jan 26. [Epub ahead of print]

免疫病理研究部

  1. Sato, Y, Suzuki H, Sato T, Suda T, Yoda T, Iwakura Y and Chida D. The role of endogenous glucocorticoid in lymphocyte development in MC2R-/- mice.
 Biochem. Biophys. Res. Commun. 403: 253,2010.
  2. Cui, CH, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, Terai M, Suzuki H and Umezawa A. Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy. 
 Hum. Mol. Genet. 20 Sato, T., Abe, T., Chida, D., Nakamoto, N., Hori, N., Kokabu, S., Sakata, Y., Tomaru, Y., Iwata, T., Usui, M., Aiko, K., Yoda, T., Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. FEBS Lett. 584: 817-824 (2010): 235,2010.
  3. Matsuwaki T, Nishihara M, Sato T, Yoda T, Iwakura Y. Chida D, Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2–deficient mice. Endocrinology 151: 5489-5496,2010.
  4. Chi HT,　Vu HA, Iwasaki R, Nagamura F, Tojo A, Toshiki Watanabe T, Sato Y: Detection of exon 12 type A mutation of NPM1 gene in IMS-M2 cell line. Leukemia Research 34:261-262,2010
  5. Chi HT, Ly BTK, Taguchi T, Watanabe T, Sato Y: All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein. J Exp Clin Cancer Res 29:165,2010.
  6. Sato, T., Chida D., Iwata, T., Usui, M., Hatori K., Abe, T., Takeda S., Yoda, T. Non-neuronal regulation and repertoire of cholinergic receptors in organs.  BioMolecular Concepts. Volume 1: 357–366,2010.
  7. Vu HA, Beppu Y, Chi HT, Sasaki K, Yamamoto H, Xinh PT, Tanii T, Hara Y, Watanabe T, Sato Y, Ohdomari I, Green Tea Epigalocatechin gallate (EGCG) Exhibits anticancer effect in Human Pancreatic Carcinoma Cells via Inhibition of both Focal Adhesion Kinase and Insulin-like Growth Factor-I Recepto.  J Biomed Biotechol, Article ID 290516, 8 pages, 2010 doi:10.1155/2010/290516

肝炎・免疫研究センター

  1. Xu S, Kangwanpong D, Seielstad M, Srikummool M, Kampuansai J, Jin L, Consortium H P-A S.　Genetic evidence supports linguistic affinity of Mlabri--a hunter-gatherer group in Thailand. BMC Genet 11:18, 2010.
  2. Murayama A, Weng L, Date T, Akazawa D, Tian X, Suzuki T, Kato T, Tanaka Y, Mizokami M, Wakita T, Toyoda T. RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells. PLoS Pathog 6(4):e1000885, 2010
  3. Takahashi H, Akazawa D, Kato T, Date T, Shirakura M, Nakamura N, Mochizuki H, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Suzuki T, Wakita T. Biological properties of purified recombinant HCV particles with an epitope-tagged envelope. Biochem Biophys Res Commun 395 (4):565-71, 2010.
  4. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung U I, Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 16 (6):678-86, 2010.
  5. Kurbanov F, Tanaka Y, Matsuura K, Sugauchi F, Elkady A, Khan A, Hasegawa I, Ohno T, Tokuda H, Mizokami M. Positive selection of core 70Q variant genotype 1b hepatitis C virus strains induced by pegylated interferon and ribavirin. J Infect Dis 201 (11):1663-71, 2010.
  6. Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchottaworn C, Manosuthi W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S, Tokunaga K. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun 11 (5):416-22, 2010
  7. Panduro A, Roman S, Khan A, Tanaka Y, Kurbanov F, Martinez-Lopez E, Campollo O, Hernandez-Nazara Z, Mizokami M. Molecular epidemiology of hepatitis C virus genotypes in west Mexico. Virus Res 151 (1):19-25, 2010.
  8. Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 139 (2):499-509, 2010.
  9. Roman S, Tanaka Y, Khan A, Kurbanov F, Kato H, Mizokami M, Panduro A. Occult hepatitis B in the genotype H-infected Nahuas and Huichol native Mexican population. J Med Virol 82 (9):1527-36, 2010.
  10. Akkarathamrongsin S, Sugiyama M, Matsuura K, Kurbanov F, Poovorawan Y, Tanaka Y, Mizokami M. High sensitivity assay using serum sample for IL28B genotyping to predict treatment response in chronic hepatitis C patients. Hepatol Res 40 (10):956-62, 2010.
  11. Elkady A, Tanaka Y, Kurbanov F, Sugauchi F, Sugiyama M, Khan A, Ali E M, Mouhamed L, Abou El-Fetouh S, Abdel-Hameed A R, Mizokami M. Performance of two Real-Time RT-PCR assays for quantitation of hepatitis C virus RNA: Evaluation on HCV genotypes 1-4. J Med Virol 82 (11):1878-88, 2010.
  12. Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M. ITPA gene variant protects against anemia induced by pegylated interferon-alpha and ribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol Res 40 (11):1063-1071, 2010.
  13. Adachi S, Tajima A, Quan J, Haino K, Yoshihara K, Masuzaki H, Katabuchi H, Ikuma K, Suginami H, Nishida N, Kuwano R, Okazaki Y, Kawamura Y, Sasaki T, Tokunaga K, Inoue I, Tanaka K. Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population. J Hum Genet 55 (12):816-21, 2010.
  14. Ito K, Qin Y, Guarnieri M, Garcia T, Kwei K, Mizokami M, Zhang J, Li J, Wands J R, Tong S. Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site. J Virol 84 (24):12850-61, 2010.
  15. Mizokami M. Hepatitis B Virus and Its Genotypes ; New development in Japan. Japan Medical Assosiation Journal 53 (4):248-249, 2010
  16. Tanaka Y, Nishida N, Sugiyama M, Tokunaga K, Mizokami M. lambda-Interferons and the single nucleotide polymorphisms: A milestone to tailor-made therapy for chronic hepatitis C. Hepatol Res 40 (5):449-60, 2010.
  17. Sako A, Yasunaga H, Horiguchi H, Hashimoto H, Masaki N, Matsuda S. Acute hepatitis B in Japan: Incidence, clinical practices and health policy. Hepatol Res 41 (1):39-45, 2011.
  18. Kuno A, Ikehara Y, Tanaka Y, Angata T, Unno S, Sogabe M, Ozaki H, Ito K, Hirabayashi J, Mizokami M, Narimatsu H. Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray. Clin Chem 57 (1):48-56, 2011.
  19. Kusakabe A, Tanaka Y, Inoue M, Kurbanov F, Tatematsu K, Nojiri S, Joh T, Tsugane S, Mizokami M. A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan. J Gastroenterol 46 (1):117-24, 2011.
  20. Wu S, Imazeki F, Kurbanov F, Fukai K, Arai M, Kanda T, Yonemitsu Y, Tanaka Y, Mizokami M, Yokosuka O. Evolution of hepatitis B genotype C viral quasi-species during hepatitis B e antigen seroconversion. J Hepatol 54 (1):19-25, 2011.
  21. Ishiguro S, Inoue M, Tanaka Y, Mizokami M, Iwasaki M, Tsugane S. Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma: A population-based cohort study (JPHC Study). Cancer Lett 300 (2):173-9, 2011.
  22. Gulube Z, Chirara M, Kew M, Tanaka Y, Mizokami M, Kramvis A. Molecular characterization of hepatitis B virus isolates from Zimbabwean blood donors. J Med Virol 83 (2):235-44, 2011
  23. Sugiyama M, Tanaka Y, Nakanishi M, Mizokami M. Novel Findings for the Development of Drug Therapy for Various Liver Diseases:Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C. J Pharmacol Sci, 2011.
  24. Koike A, Nishida N, Yamashita D, Tokunaga K. Comparative analysis of copy number variation detection methods and database construction. BMC Genet 12:29, 2011.
  25. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M. Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol 54 (3):439-48, 2011.
  26. Sugauchi F, Tanaka Y, Kusumoto S, Matsuura K, Sugiyama M, Kurbanov F, Ueda R, Mizokami M. Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancy. J Med Virol 83 (3):412-418, 2011.
  27. Yuen M F, Ka-Ho Wong D, Lee C K, Tanaka Y, Allain J P, Fung J, Leung J, Lin C K, Sugiyama M, Sugauchi F, Mizokami M, Lai C L. Transmissibility of Hepatitis B Virus (HBV) Infection through Blood Transfusion from Blood Donors with Occult HBV Infection. Clin Infect Dis 52 (5):624-32, 2011.
  28. Okamoto K, Tokunaga K, Doi K, Fujita T, Suzuki H, Katoh T, Watanabe T, Nishida N, Mabuchi A, Takahashi A, Kubo M, Maeda S, Nakamura Y, Noiri E. Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet, 2011.
  29. Otowa T, Kawamura Y, Sugaya N, Yoshida E, Shimada T, Liu X, Tochigi M, Umekage T, Miyagawa T, Nishida N, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T. Association study of PDE4B with panic disorder in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry 35 (2):545-9, 2011
  30. Kusumoto S, Tanaka Y, Mizokami M, Ueda R. Clinical significance of hepatitis B virus (HBV)-DNA monitoring to detect HBV reactivation after systemic chemotherapy. J Clin Oncol 29 (4):e100; author reply e101, 2011.
  31. Kusumoto S, Tanaka Y, Ueda R, Mizokami M. Reactivation of hepatitis B virus following rituximab-plus-steroid combination chemotherapy. J Gastroenterol 46 (1):9-16, 2011
  32. Yokosuka O, Kurosaki M, Imazeki F, Arase Y, Tanaka Y, Chayama K, Tanaka E, Kumada H, Izumi N, Mizokami M, Kudo M. Management of hepatitis B: Consensus of the Japan Society of Hepatology 2009. Hepatol Res 41 (1):1-21, 2011.

免疫診療部

  1. Yanai H, Masui Y, Yoshikawa R, Kunimatsu J, Kaneko H. Dipeptidyl peptidase-4 inhibitor for steroid-induced diabetes. World J Diabetes 1: 99-100, 2010.
  2. Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H, Sekigawa I.. Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol 28: 311-317, 2010.
  3. Kobayashi M (Masafumi Kobayashi), Takahashi Y, Yamashita H, Kaneko H, Mimori A. Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome. Mod Rheumatol 21: 92-96, 2011.

独立行政法人 国立国際医療研究センター研究所　〒162-8655　東京都新宿戸山1-21-1　TEL (03)3202-7181 FAX(03)3202-7364
Copyright (c) 2005 Research Institute, National Center for Global Health and Medicine