| Program |
Department |
Head |
Capacity |
| Development of
local drug delivery system (DDS) by targeting
peptides |
Department of
Intractable Diseases |
Yukihito
Ishizaka |
1 |
| We are trying to
develop a local DDS (drug delivery system) by using
peptide and antibody specific for tumors. Tumors will be
visualized by MRI combined with magnetic nanoparticles
conjugated with targeting molecules. Local DDS will be
possible by using temperature-sensitive ripozomes that
contain anti-caner agents. |
| Role of
retrotransposon in human diseases |
Department of
Intractable Diseases |
Yukihito
Ishizaka |
1 |
| Our genome has
movable elements that are occasionally integrated into
the genome once 30-100 births. This project is to
identify the role of retrotransposon in human diseases
and clarify the mechanism of retrotransposition. This
project also covers identification of human endogenous
retroviruses involved in human diseases. |
| Bio and medical
applications of nanotechnology and supercritical
fluids |
Department of
Medical Ecology and Informatics |
Kenji Yamamoto |
1 or 2 |
| The applicants are
expected to pursue medical applications of materials
produced in hydrothermal reactions and of the functional
nanoparticles, for example, dyeing materials for
vitreous body, or fluorescent particles for drug
delivery. No prior knowledge is necessary. |
| Fundamentals of
clinical research |
Department of Clinical Research and Informatics |
Takuro Shimbo |
1 or 2 |
The objectives of
the course are to learn fundamental knowledge and skills
for conducting clinical researches. The course covers
topics of biostatistics, clinical epidemiology,
systematic reviews and cost-effectiveness analysis. The
curriculum includes
1)reading basic textbooks,
2)exercise of PC statistical software, 3)conferences,
4)session for critical appraisal of medical literature,
5)designing your own research and writing
proposal. |
| Peritoneal
cellular and humoral responses to surgical stress |
Department of
Gastroenterology |
Taeko Dohi |
1 |
| Aiming prevention
of postsurgical peritoneal adhesion, cancer metastasis,
and inflammation, we will analyze peritoneal exdating
cells, cytokines and chemokine at the surgical
stress. |
| Epigenetic changes
of inflammation-associated cancer in gastrointestinal
tract |
Department of
Gastroenterology |
Taeko Dohi |
1 |
| The purpose of this
study is to clarify the mechanism of
inflammation-associated cancer. We will investigate the
inflammation- and cancer-associated epigenetic changes
including DNA hypermethylation in humans and mouse
models. |
| Neuronal cell
differentiation from skin-derived cell |
Department of
Tissue Regeneration |
Hitoshi Okochi |
1 |
This program provides opportunity to learn the
methods of utilizing skin as a stem cell source. We
isolate skin-derived precursor cells from mice and make
spheres by using the floating culture method
(neurosphere method). These spheres are
differentiated then into neuronal cells under several
conditions. Neuronal cells are identified as neurons by
morphological observation and immunohistochemical
analysis using several antibodies against neuronal
marker proteins. |
| An Introduction to
Epidemiology for Clinical Research |
Department of
Epidemiology and International Health |
Tetsuya Mizomue |
1 or 2 |
| The objectives of
this course are to understand the design and conduct of
epidemiologic method and to develop practical skills for
clinical research. After completing this course,
participants should be able to 1) design case-control
study, cohort study, and randomized controlled trial, 2)
control bias and random variation and calculate sample
size, 3) develop a questionnaire, and 4) conduct
informed consent procedure. |
| Molecular
epidemiology of nosocomial infection |
Department of
Infectious Diseases |
Teruo Kirikae |
1 |
| Nosocomial
infection measures are developed based on molecular
epidemiological analysis of nosocomial pathogens, such
as MRSA, multidrug-resistant Pseudomonas aeruginosa and
Mycobacterium tuberculosis. Only few doctors, who would
like to gain a license for Infection Control Doctor in
the future and to become one of the core members of
Infection Control Team, have directly analyzed
nosocomial pathogens in microbiology laboratories. In
this program, a basic concept of clinical microbiology
is acquired through the investigation of nosocomial
infection cases and handling of nosocomial
pathogens. |
| Culture technique and
molecular analysis of primate embryonic stem cells |
Department of Hematology |
Akira Yuo |
1 |
| Main educational
programs of our department are to have an experience
with you to cultivate the immature primate embryonic
stem cells in the non-feeder conditions and induce the
differentiation of these cells also in the non-feeder
culture conditions. In addition, we provide you with the
opportunity to analyze mRNA and proteins before and
after differentiation in primate embryonic stem
cells. |
| Molecular analysis in
lineage commitment of immature thymocytes |
Department of Pathology |
Harumi Suzuki |
1 or 2 |
| Th-POK is a
transcription factor that is critically involved in
determination of lineage fate of CD4-helper and
CD8-killer T cells. To elucidate the function of Th-POK
in the lineage commitment process in the thymus,
molecular and biochemical analysis of the Th-POK gene
will be performed in this program. You will learn basic
techniques in cellular biochemistry such as cell
culture, gene cloning, protein analysis etc., as well as
knowledge about recent immunology. |
| Immunohistological studies
on the pathogenesis of chronic renal diseases using
animal models |
Department of Clinical
Pharmacology |
Yasuhiro Natori |
1 |
| Using kidney
samples of rat models for several chronic renal diseases
including crescentic glomerulonephritis, membranous
nephropathy, and diabetic nephropathy, trainees are
scheduled to perform immunostaining for leukocyte
markers as well as proteins that have been shown or are
assumed to be involved in the progression of chronic
renal diseases. The target molecules include
extracellular matrix proteins, cytokines, and
transcription factors. Through this program, trainee
will learn some immunostaining techniques and experience
a part of ongoing research project on the pathogenesis
of kidney diseases. |
| Searching new
autoantigens in autoimmune disease patients |
Department of
Community Health and Medicine |
Satoshi Takaki |
1 or 2 |
| Autoantibodies,
which recognize self antigens, are one of critical
diagnostic marker for various autoimmune diseases, and
play roles in development and maintenance of the
diseases. We are going to examine whether a newly
identified ribonucleic protein (RNP) could be a target
of autoantibodies in patients and be a new diagnostic
marker. In this program, you will experience several
protocols commonly used in lab, such as ELISA,
immunoblotting, protein expression and
purification. |
